Autopsy findings in COVID-19 infection-related death: a systematic review
Egyptian Journal of Forensic Sciences volume 12, Article number: 22 (2022)
Coronavirus-19 disease (COVID-19) has been declared as pandemic by the World Health Organization (WHO) in March 2020. As of 28 November 2021, there were more than 260 million cases and nearly 5.2 million deaths caused by COVID-19. The most affected system by COVID-19 infection was the respiratory system although several other studies suggested multi-organ involvement with pathophysiology that was not clearly understood. Autopsy findings were beneficial to researchers to determine the mechanism behind these organ failures. The objective of this review was to summarize the autopsy findings related to COVID-19 death.
Online literature search was conducted via online databases such as Scopus, PubMed and Google Scholar. The keywords inputted during the search were “post-mortem”, “autopsy” and “COVID-19” in title, abstract and keywords. The inclusion criteria were the topic related with the title of this review, published in 2020–2021, have full text available and in English language. Any articles that were not related, duplicated studies, review articles including systematic review and meta-analysis and in other languages were excluded.
A total of 20 articles were included in this review. The articles reviewed were mostly case reports and case series while others were case-control and cohort study ranging from one to 348 cases. Majority were originated from the United States of America (USA).
The most frequent system described in autopsy findings in COVID-19 death was the respiratory system, with the most common histological finding of diffuse alveolar damage (DAD). Majority of the findings of other organs were related to chronic diseases.
In early 2020, the world has been widely affected with newly found and highly infectious COVID-19. World Health Organization (WHO) has declared this infection as pandemic in March 2020.(World Health Organization (WHO) n.d.-a) The number of cases worldwide has been in ups-and-downs trend as the advancement of medical technology such as the production of COVID-19 vaccines and the newly discovered variants of COVID-19. Despite the procurement of vaccines around the world, WHO advised all the citizens to practice usage of face masks, hand hygiene and physical distancing as these were part of the strategy to curb COVID-19 infection. As of the end of November 2021, there were more than 260 million cases and approximately 5.2 million deaths have been reported globally.(World Health Organization (WHO) n.d.-b)
It has been clear that the most affected system by COVID-19 is the respiratory system although there were several studies that suggested multiple system involvement. COVID-19 infection could also lead to acute kidney injury, acute liver injury, cardiovascular diseases and haematological abnormalities. On top of that, people with comorbidities such as cardiovascular diseases, hypertension, obesity and others were at a higher risk for multiple system involvement.(Mokhtari et al. 2020; Zaim et al. 2020) However, the pathophysiology behind these organ failures was not well understood. Autopsy investigations of COVID-19 deaths were important to determine the cause of multi-organ failures which will subsequently help in proper management strategy for COVID-19 infection.
Thus, the aim for this article review was to collect and summarize the findings of autopsy of COVID-19 related deaths.
The articles included must be related with the topic of this review, in English language, have full-text availability and be published from the year 2020 to 2021 which corresponds with the period of COVID-19 infection. Any articles that were not related with the topic, duplicated studies, review articles including systematic review and meta-analysis and in any other languages were excluded from the review. Duplicated studies were determined by comparing the title of the articles and the authors’ names.
Literature search strategy was conducted on 15th November 2021 via online electronic databases such as Scopus, PubMed and Google Scholar. The keyword inputted for filtering during the search were “post-mortem”, “autopsy” and “COVID-19” in title, abstract and keywords. The data items from the articles were extracted into a spreadsheet consisting of the title of publication, authors and year of publication, the location of study, study design, number of cases, and key findings.
The titles of the studies were screened and the abstracts were analysed related to the title of this review. Full text was then obtained and studies that fulfilled the inclusion and exclusion criteria were included in the review. The bibliographic references of selected papers were examined to ensure the relevance of those studies. Figure 1 has visualized the flowchart of the reviewing process.
From 3086 articles searched in the above-mentioned databases, 45 full texts were selected after assessment. The bibliography of the selected papers was examined and cross-referenced for further relevant literature. The articles were selected, data were collected and the details were assessed independently by two reviewers so as to mitigate the study risk of bias assessment. These researchers, with medical background, examined the articles and conducted certainty assessment pertaining to the autopsy findings in COVID-19 death. No unpublished and grey literatures were selected. From this approach, a number of 20 relevant papers were included in this review. The rationale of the synthesis methods was monitored by the scientist with systematic review background to ensure the visualisation of the data and tabulation of the data were in a presentable manner. Table 1 was a summary of the systematic review of autopsy findings in COVID-19 death.
This systematic review has been registered with the National Medical Research Register (NMRR) under the research ID RSCH-ID-22-00025-0IP and the ethical clearance was obtained from the medical research and ethics committee (MREC) with reference to NMRR ID-22-00184-DD8. This systematic review only involved a literature search from the website and did not involve any human subjects or any direct intervention on human subjects. The authors declared that there was no competing interest and no financial support throughout the review process.
In general, most of the publications were case reports and case series with two case-control study and 1 cohort study. Majority of the articles were published in the year 2020. As for the country of origin, 8 articles originated from the USA, followed by two from Italy, two from Germany and one each from Switzerland, China, Romania, Turkey, Brazil, Zambia, Ghana and France. The lowest number of cases being examined and reported was one whilst the highest was 348 cases. The age of the reported cases varied with the majority of the deceased being elderly. Almost all studies described the majority of the cases have known pre-existing comorbidities with cardiovascular disease and hypertension being the frequently stated risk factors.
Almost all studies reported on the autopsy pulmonary findings in COVID-19 death except for one article reported by Santoriello et al. (2020) that focused on kidney pathology in COVID-19 deaths. Heavy, firm and edematous lungs have been mostly described in (Roden et al. 2021; Konopka et al. 2020; Falasca et al. 2020; Barton et al. 2020; Keresztesi et al. 2020; Attoh et al. 2020) There was patchy to diffuse consolidation in the lungs as mentioned by (Fig. 2).(Roden et al. 2021; Keresztesi et al. 2020; Menter et al. 2020; Arslan et al. 2021)
There were also changes in colour and pattern of the lungs in COVID-19 patients. Edler et al. (2020) described a mosaic-like pattern of pale and dark purple lung sections with prominent capillary drawings. Other than that, Barton et al. (2020) reported a mottled red appearance of the lungs from one of the cases they examined. There was pleural effusion noted in the studies of (Roden et al. 2021; Falasca et al. 2020)
Almost all studies except the study by Santoriello et al. (2020) reported on the histological features of lungs in COVID-19 cases. The most reported finding in all those studies is the features of diffuse alveolar damage (DAD) in the lung histology. Proliferative to exudative diffuse alveolar damage characterized with hyaline membrane deposition, alveolar necrosis, type II pneumocytes hyperplasia and the presence of lymphocytes, macrophages, multinucleated giant cells were considered as distinctive features of COVID-19 infection. Bloom et al. (2020) described the findings as multifocal to diffuse alveolar necrosis and bronchiolar respiratory epithelial necrosis. On the other hand, Edler et al. (2020) reported a diffuse alveolar damage with an accumulation of activated type II pneumocytes, fibroblasts, protein-rich exudate and hyaline membranes. A prominent capillary congestion with hyaline membrane formation, reactive pneumocytes changes and the presence of syncytial cells were the most prominent findings in the study of Menter et al. (2020) (Fig. 3).
There were several studies that described microscopic thrombi formation in the lung histology. Eight out of ten patients in the study of Duarte-Neto et al. (2020) have fibrinous thrombi in alveolar vessels. In addition to that, a study in Northern Italy revealed 33 out of 38 cases have platelet-fibrin thrombi deposited in small alveolar vessels.(Carsana et al. 2020) Elsoukkary et al. (2021) reported 84% of the cases to have microscopic and/or macroscopic thrombi at autopsy and most commonly seen was in the respiratory system. This study also reported the coagulation profile of all patients was prolonged, with the mean prothrombin time of 24 s and mean activated partial thromboplastin time of 51.6 s.
Pathology of the cardiovascular system was mostly chronic diseases related changes. Duarte-Neto et al. (2020) described the extrapulmonary findings in COVID-19 patients can be categorized into findings related to comorbidities, attributed to shock and unascertained aetiologies. From the study, nine cases were reported with the presence of myocardial hypertrophy and myocardial fibrosis. Myocardial hypertrophy was one of the common findings of the cardiovascular system described in these studies by (Attoh et al. 2020; Menter et al. 2020; Elsoukkary et al. 2021; McMullen et al. 2021) In the study of Menter et al. (2020), 70% of the cases have severe generalized atherosclerosis of the aorta.
Apart from that, there were several studies reported features of cardiac inflammation in the COVID-19 patients. There were two cases of myositis and two cases of mild lymphomononuclear myocarditis in the study of Duarte-Neto et al. (2020). In the study of Falasca et al. (2020), active myocarditis was observed microscopically, characterized by lymphocytic infiltrates and associated with focal myocyte necrosis. There was one case reported by Edler et al. (2020) with a feature of myocarditis such as small lymphocytic infiltrates in the right ventricle of the heart.
The most common finding of the renal system was mainly described as acute tubular injury. Menter et al. (2020) reported features such as widened tubular lumina, flattened tubular epithelium and interstitial oedema which were related to the findings of acute tubular injury. In the study of Santoriello et al. (2020) which more specified towards the kidney pathology in COVID-19 cases, acute tubular injury was the most common finding, especially in patients with acute kidney injury. Acute tubular injury in this study was graded into absent, mild and moderate-to-severe based on the histological changes and its distribution. From their study, they revealed that despite 11 cases that cannot be determined due to autolysis, 39% of the remaining cases were absent or minimal, 39% were mild and 23% were moderate-to-severe.
Other than that, there were also findings related to chronic diseases described in these findings. Chronic changes such as arteriosclerosis, intimal fibrosis of the arteries and vascular scarring were found in the majority of the cases (Fig. 4a, b).(Menter et al. 2020) These findings were also similar to the study of Santoriello et al. (2020) which reported findings such as arteriosclerosis, interstitial fibrosis and tubular atrophy. Such findings also could be found in the study of Duarte-Neto et al. (2020) and Elsoukkary et al. (2021).
Hepatobiliary and other systems
Congested liver was among the common finding described in these studies of, Falasca et al. (2020), Attoh et al. (2020) and Edler et al. (2020). Other than that, steatosis or fatty changes of liver was also one of the frequently found pathology in these studies by Falasca et al. (2020), Menter et al. (2020) and Elsoukkary et al. (2021). Sign of shock associated necrosis of the liver was described by Menter et al. (2020).
Apart from those liver pathology, haematopoietic system such as spleen and lymph nodes pathology was one of the extrapulmonary organs that often described in these articles (Fig. 4c, d). Elsoukkary et al. (2021) reported in their study that except for one case with splenic marginal zone lymphoma, the lymph nodes were in preserved architecture, morphologically intact germinal centre, paracortical areas and patent sinuses. The subcapsular and intraparenchymal sinuses contained CD20 positive large, transformed cells with prominent nucleoli and amphophilic cytoplasm. These transformed cells were also seen in vascular sinuses and paracortical regions.
One of the commonest complications for COVID-19 infections was the involvement of the respiratory system. There were numerous studies that showed lung pathology of the deceased patients who had COVID-19 infection. The lung pathological features of COVID-19 found were similar to severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) (Edler et al. 2020).
In addition to that, some studies show that lung injury was the main cause of death in these patients. The virus was believed to infect the epithelial lining cells of the respiratory tract using the angiotensin-converting enzyme (ACE) 2 enzymes as a viral receptor leading to DAD, edema, and a marked increase in lung weights at autopsy.(Roden et al. 2021; Konopka et al. 2020; Falasca et al. 2020; Barton et al. 2020; Keresztesi et al. 2020; Attoh et al. 2020)
The major histological feature in the lung is diffuse alveolar damage with hyaline membrane formation, alongside microthrombi in small pulmonary vessels. It appears that there is a high incidence of deep vein thrombosis, especially the patients under intensive care despite a prophylactic dose of anticoagulant. Pulmonary embolism and risk for arterial thrombotic disease appear to be increased among COVID-19 decedents, suggesting endothelial involvement, but more studies are needed. (Maiese et al. 2021a; Zanza et al. 2021; Maiese et al. 2020)
Cytokine storm has recently emerged as a key aspect in this disease with affected patients showing high levels of several key pro-inflammatory cytokines, such as IL-1, IL-2, IL-6 and many more. These pro-inflammatory cytokines aggravate interstitial pneumonia and evolve in viral sepsis with prominent hypercoagulability.(Maiese et al. 2020) These agents can be investigated in autopsies cases as part of therapeutic strategies in the near future.(Zanza et al. 2022)
There was some evidence that COVID-19 patients have a significant impact towards their cardiovascular system. Multiple authors have reported clinical evidence of cardiac injury seen in the form of elevated troponins, and pathologically concurrent myocardial infarction and myocarditis.(Falasca et al. 2020) The most significant histologic finding in our cohort was the presence of intramyocardial thrombi. At present, it was known that endothelial injury and thrombosis were seen in patients with COVID-19 infection as a part of microangiopathy.(Elsoukkary et al. 2021) Other than that, ACE2 was highly expressed in the heart, providing opportunity for ACE2-dependent myocardial infarction. Cytokine storm from systemic inflammation and the hypoxic state from acute respiratory distress syndrome (ARDS) inducing excessive extracellular calcium levels leading to myocyte apoptosis were also possible mechanisms of damage. Surge in cytokine levels due to hyperinflammatory response or secondary hemophagocytic lymphohistiocytosis and increased myocardial demand in the setting of acute infection can lead to atherosclerotic plaque instability and myocardial injury, hence increasing the risk of acute myocardial infarction. On the other hand, the finding for gross examination of the heart showed myocardial ventricular hypertrophy and dilatation, mainly of the right cavity, in a considerable number of cases. Acute right coronary artery thrombosis was observed in one case. The most frequent microscopic findings inclusive of cardiomyocyte hypertrophy (Fig. 5l).(Falasca et al. 2020; Duarte-Neto et al. 2020; Elsoukkary et al. 2021)
However, some studies reported that the link of COVID-19 and viral-associated myocarditis does not appear to have a major role in the cardiac injury in these patients. Some of the patients had underlying congenital heart disease requiring multiple surgeries, and the myocarditis was temporally distant, arising earlier than viral symptoms. Therefore, it was believed that this could be unrelated to the viral infection. No other patient had any inflammatory infiltrates in the heart. No viral inclusion was observed in any cases. (Elsoukkary et al. 2021)
Post mortem analysis of the myocyte can be subjected for immunohistochemical examination as there are studies that revealed the constant presence of CD3+ and CD8+ cytotoxic lymphocytes and CD68+ macrophages. COVID-19 leads to a systemic inflammatory response and a constant prothrombotic state.(Maiese et al. 2021b)
In relation to the renal system, some studies mentioned that COVID-19 infection can cause acute tubular injury which may be related to tubular ischaemia alone such as hemodynamic changes or could be further exacerbated by direct viral infection, cytokine mediated injury, or drug-related tubular toxicity. The acute tubular damage was described as flattened tubular epithelium and lumens containing sloughed epithelial lining cells, granular casts, Tamm-Horsfall protein and intraluminal accumulation of cellular debris in focal areas. In addition, considerable renovascular disease was present with moderate-to-severe sclerosis in 80% of cases, atheroemboli, papillary necrosis, and glomerular fibrin thrombi. (Menter et al. 2020)
However, the type of alteration seems to be related to hypoxia and responsible for terminal renal failure, rather than directly associated with the virus, although the tubular epithelium has a high expression of ACE-2 receptors. (Darriverre et al. 2020) Thus, it could be believed that the infection of COVID-19 was indirectly causing damage to the kidney.
Hepatobiliary and other systems
Liver was one of the affected organs as the infection progresses. Studies showed evidence of liver involvement in the form of steatosis and some cases, necrosis was observed. Apart from steatosis, microscopically it exhibits chronic congestion, lymphocytic infiltrates especially in the portal or periportal tract, hepatocyte necrosis as well as hyperplasia and hypertrophy of the Kupffer cells. The presence of typical coronavirus particles in the cytoplasm, mostly without membrane-bound vesicles, has also been reported. (Falasca et al. 2020)
Involvement of the central nervous system including hypoxic changes, followed by ischemic and haemorrhagic lesions and reactive astrogliosis and microgliosis had been observed. These findings do not seem to be specific to COVID-19 infection but brain examination as part of COVID-19 routine autopsies should be included as part of standardized requirements for further confirmation of the findings. (Maiese et al. 2021c)
During this pandemic, countless people of various demographics were infected by the COVID-19 virus. However, the most significant group that was hit the worst during this pandemic was those who had previously been diagnosed with comorbidities, hence most of the deceased were older people with pre-existent medical illnesses. The fact that most microscopic findings could be attributed to chronic illnesses and most of the pathology described was universally applied to the older population that suffers from the most common chronic diseases. The currently available information regarding the COVID-19 infection-related death described the systemic target of the infection of mostly respiratory system involvement, followed by cardiovascular, renal and hepatobiliary systems. Autopsy studies allow the researchers to study the flow, pattern and mechanism of the infection that affects the body systems. More research could be done to study the effects of COVID-19 infection on the body's natural defences in order to provide an early warning system and strategies to prevent the infection from becoming fatal. Having said that, there are many issues in relation to future litigation after the COVID-19 pandemic is highlighted especially involving the substandard of care due to various reasons. From the autopsies point of view, the issues of trained personnel, the adequate personal protective equipment as well as the facilities served as the foundation to run a quality autopsy, which might vary from each centre. A uniform COVID-19 post mortem diagnostic protocol has not been developed to date. International collaboration is essential, standardized diagnostic criteria are fundamental requirements as a way forward plan. (Maiese et al. 2021a; Maiese et al. 2021d)
Availability of data and materials
United States of America
Diffuse alveolar damage
World Health Organization
Cause of death
Severe acute respiratory syndrome
Middle East respiratory syndrome
Acute respiratory distress syndrome
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We would like to thank the Dean, Kulliyyah of Medicine, Directors of SASMEC @IIUM and all the co-workers in the above-named hospital who has contributed directly or indirectly to the report.
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Sofizan, N.M.F.B.N., Rahman, A.F.B.A., Soon, L.P. et al. Autopsy findings in COVID-19 infection-related death: a systematic review. Egypt J Forensic Sci 12, 22 (2022). https://doi.org/10.1186/s41935-022-00280-8