Feature | Site | Grade | 0–6 h |  > 6–24 h |  > 24–72 h |  > 72–240 h |  > 240 h | p-value |
---|---|---|---|---|---|---|---|---|
Myelin degradation via H&E staining [n (%)] | CC | 1 (normal) | 66.7% | 54.5% | 7.1% | 6.7% | 8.3% | 0.03 |
2/3/4 (mild, moderate, severe) | 33.3% | 45.5% | 92.8% | 93.3% | 91.7% | |||
GWMI | 1 (normal) | 100% | 90% | 50% | 41.7% | 30% | 0.003 | |
2/3/4 (mild, moderate, severe) | Â | 10% | 50% | 58.3% | 70% | |||
IHC β-APP and NFP [median (min–max] | CC | - | 6 (1–8) | 7 (1–10) | 8 (1–10) | 9 (4–10) | 7 (1–10) |  < 0.001 |
Thalamus | 1.5 (0–9) | 4 (1–8) | 3 (1–10) | 5 (1–10) | 5 (5–10) | 0.1 | ||
MB | 2.5 (0–7) | 3 (0–7) | 5 (1–9) | 4 (0–10) | 4 (2–8) | 0.2 | ||
Pons | 2.5 (0–8) | 6 (2–9) | 6.5 (1–10) | 7 (2–10) | 7 (1–9) |  < 0.001 | ||
MO | 6 (0–9) | 4 (2–8) | 4 (1–10) | 3 (1–9) | 3 (2–9) | 0.2 | ||
GWMI | 3 (0–5) | 3 (1–8) | 4 (1–9) | 5 (1–8) | 3 (2–7) | 0.3 | ||
Astrogliosis IHC-GFAP [median (min–max] | CC | - | 162 (24–278) | 91 (24–461) | 10 2 (18–322) | 137 (23–362) | 183 (13–449) | 0.3 |
GWMI | - - | 160 (48–246) | 198 (146–394) | 214.5 (41–401) | 191 (93–563) | 325.5 (47–482) | 0.2 | |
Microglial reaction [n (%)] | - | - | 41.6 | 54.5 | 71.4 | 80 | 83.3 | 0.3 |