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Egyptian Journal of Forensic Sciences
Fig. 7 | Egyptian Journal of Forensic Sciences

Fig. 7

From: Cytotoxicity associated with acute and chronic administration of synthetic cannabinoids “Strox” in the brain, liver, heart, and testes of male albino rats: histological and immunohistochemical study

Fig. 7

Photomicrographs of sections in the liver stained with H&E (×400). A and B Negative and positive control groups show a normal architecture of tightly packed cords of hepatocytes around the central vein and blood sinusoid in between. Polyhedral hepatocytes with acidophilic cytoplasm and rounded vesicular nuclei with prominent nucleoli are seen (arrow). Some binucleated cells are also existing (thick arrow). Blood sinusoids are lined by flattened endothelial cells (arrowhead). C Acute treated group reveals dilated congested blood sinusoids (arrowhead), and most of the hepatocytes appear with vacuolated cytoplasm (arrows). D Chronic treated group showing disturbed liver architecture with dilated blood sinusoids (curved arrow). Hepatocytes appear with vacuolated cytoplasm (arrows); some have degenerated nuclei (arrowheads), and others have irregularly shaped nuclei (thick arrow). E Chronic withdrawal group reveals degenerated hepatocytes. Liver cells appear with multiple large, coalesced vacuoles and degenerated nuclei (arrows). Congested central vein (arrowhead) and dilated congested blood sinusoid (curved arrow) are also seen

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