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Egyptian Journal of Forensic Sciences
Fig 4 | Egyptian Journal of Forensic Sciences

Fig 4

From: Cytotoxicity associated with acute and chronic administration of synthetic cannabinoids “Strox” in the brain, liver, heart, and testes of male albino rats: histological and immunohistochemical study

Fig 4

Photomicrographs of sections in the cerebellar cortex immunohistochemically stained with cannabinoid receptor 1 (CB1) (×400). A and B Negative and positive control groups show strong positive immunoreaction of Purkinje cells (thick arrow) as well as the nuclei of some cells in the molecular layer (arrowhead). The arrow points to the Purkinje dendrites in the molecular layer. C Acute treated group shows a decrease in positive reaction in Purkinje cells (arrows) compared to control groups. D Chronic treated group reveals few positive reactions in Purkinje cells (arrow). E Chronic withdrawal group shows a mild increase in positive reaction in Purkinje cells (arrows) compared to the chronic group. F The bar chart shows the quantitative estimation of the mean count of CB1-positive cells. Data are expressed as the means ± SD; P < 0.001 for control groups vs acute, chronic, and chronic withdrawal groups

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