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Egyptian Journal of Forensic Sciences
Fig. 15 | Egyptian Journal of Forensic Sciences

Fig. 15

From: Cytotoxicity associated with acute and chronic administration of synthetic cannabinoids “Strox” in the brain, liver, heart, and testes of male albino rats: histological and immunohistochemical study

Fig. 15

Photomicrographs of sections in the testes stained with H&E (×100, inset ×400). A and B Negative and positive control groups show normal seminiferous tubules (arrows) lined with stratified epithelium and separated by loose interstitial connective tissue. Inset; primary spermatocytes (pr), spermatogonia (g), round spermatids (rs), and sperms (sp). Sertoli cells (arrowhead) and Leydig cells (arrow). C Acute treated group showing seminiferous tubules with wide interstitial space. Inset; show reduction in the germinal epithelium (arrowhead). D Chronic treated group reveals distortion of seminiferous tubules, sloughing of germ cells nuclei, and exfoliation into the tubular lumen (arrow). Tubular basement membrane separation (arrowhead) is also seen. Inset; show vacuolation (arrows) with disorganized seminiferous epithelium. Congested blood vessels (arrowhead) and interstitium deposition by an extremely acidophilic material (asterisk). E Chronic withdrawal group shows irregularity and distortion of seminiferous tubules. Some tubules show a decrease in the thickness of spermatogenic epithelium up to depletion with few or no sperms (asterisk). Inset; revealed vacuolar degeneration (arrow) with dilated blood vessels and interstitium deposition by extremely acidophilic material (asterisk)

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