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Egyptian Journal of Forensic Sciences
Fig. 11 | Egyptian Journal of Forensic Sciences

Fig. 11

From: Cytotoxicity associated with acute and chronic administration of synthetic cannabinoids “Strox” in the brain, liver, heart, and testes of male albino rats: histological and immunohistochemical study

Fig. 11

Photomicrographs of the longitudinal sections of left ventricular heart muscles stained with H&E (×400). A and B Negative and positive control groups show normal heart morphology with branching and anastomosing cardiac muscle fibers. Cardiomyocytes have acidophilic sarcoplasm and central vesicular nuclei (arrows). C Acute treated group showing disruption of some cardiac muscle fibers with congested blood vessels (arrow). Many deeply stained nuclei are also seen (arrowheads). D Chronic treated group showing disorganized cardiac muscle fibers with dilated blood vessels (asterisk). Degeneration and discontinuity of cardiac muscle fibers (arrows) with deeply stained irregular-shaped nuclei also appear (arrowhead). Mononuclear cell infiltration is also detected. E Chronic withdrawal group reveals dilated and congested blood vessels with disruption of cardiac muscle fibers and extravasation of blood cells (arrow). Degeneration and irregularly shaped nuclei are also detected (arrowheads)

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