Table 4 Applications of various Drugs, the technique used and the ionization mode in the DART source
Application | Technique | Ionization mode in DART source | Reference |
|---|---|---|---|
Detection of adulterants and contaminants in drugs | DART ion source coupled to an AccuTOF orthogonal TOF-MS | Both positive and negative ionization mode | (Fernandez and Cody 2006) |
DART-TOF (JEOL, Peabody, USA) | Positive ionization mode | ||
AccuTOF -MS (JEOL, Japan) with DART Ion Source (IonSense, USA) | Positive ionization mode | (Chernetsova and Bochkov 2011) | |
DART-SVP100™ Ion Source (Ionsense, USA) linked with JMS-T100LP AccuTOF (JEOL, Peabody ,USA) | Positive ionization mode | (Samms and Jiang 2011) | |
DART-SVP™ Ion Source (IonSense, USA) equipped with 6530 Accurate-Mass Quadrupole, TOF-MS (Agilent Technologies, USA) | Positive ionization mode | (Zhou and Zhang 2011) | |
DART ionization coupled to a QqTOF-MS | Both positive and negative ionization mode | (Vaclavik and Krynitsky 2014) | |
Determining the active component in several drugs/pharmaceuticals | AccuTOF-DART (JEOL, Peabody, MA) and DART Ion Source (IonSense, USA) | Positive ionization mode | (Ropero-Miller and Stout 2007; Howlett and Steiner 2011; Lesiak and Cody 2014; Chernetsova and Bochkov 2010) |
DART-SVP100™ Ion Source (Ionsense, USA) and JMS-T100LP AccuTOF (JEOL, Peabody, USA) | Positive ionization mode | (Likar and Cheng 2011) | |
AccuTOF-DART-MS (JEOL, Peabody, MA) and DART-SVPTM Ion Source (IonSense, USA) | Positive ionization mode | (Lesiak and Musah 2013; Musah and Cody 2014; Kuki and Nagy 2015) | |
DART-SVP100™ Ion Source (Ionsense, USA) and JMS-T100LP AccuTOF (JEOL, Peabody, USA) | Positive ionization mode | ||
TD-DART-MS interfaced to a JMS-T100LP AccuTOF (JEOL, Peabody, USA) | Positive ionization mode | (Sisco and Verkouteren 2017) | |
JMS-T100LP AccuTOF (JEOL USA, Peabody, MA) connected to DART-SVPTM Ion Source (IonSense, USA), along with TD-MS | Both positive and negative ionization mode | (Robinson and Sisco 2018) | |
Identifying drug residuals on surfaces bearing fingerprints or from fluid matrices | DART-SVP100™ Ion Source (Ionsense, USA) and JMS-T100LP AccuTOF (JEOL, Peabody ,USA) | Both positive and negative ionization mode | |
A DART® ion source (IonSense, USA) interfaced to AccuTOF® 100 TOF-MS (JEOL, Peabody ,USA) | Positive ionization mode | (Grange and Sovocool 2011) | |
SALDI-MS using an AXIMA TOF-MS (Shimadzu Pvt. Ltd.) API source from DART Ion Source (IonSense, USA) and JMS-T100LP AccuTOF (JEOL, Peabody ,USA) | Positive ionization mode | (Lim and Rowell 2013) | |
Identifying marker compounds in herbal drugs | AccuTOF-TLC single-reflectron TOF-MS (JEOL, Peabody ,USA) equipped with a DART Ion Source (IonSense, USA) | Positive ionization mode | |
AccuTOF-DART-MS (JEOL, Peabody ,USA) configured with a DART-SVPTM Ion Source (IonSense, USA) | Positive ionization mode | (Lesiak and Musah 2014) | |
6520 Accurate Mass quadrupole TOF-MS (Agilent Technologies, USA) equipped with a DART SVPTM Ion Source (IonSense, USA) | Positive ionization mode | (Wang and Li 2014) | |
DART Ion Source (IonSense, Japan) coupled to a JMS-T100TD TLC-TOFMS | Positive ionization mode | (Jang 2009) | |
Analysis of sexual lubricants | AccuTOF-DART (JEOL, USA) | Positive ionization mode | (Musah and Cody 2012) |
DART Ion Source (Ionsense, USA) and JMS-4000LC AccuTOF (JEOL, JAPAN) | Both positive and negative ionization mode | (Maric and Bridge 2016) | |
DART-SVP100™ Ion Source (Ionsense, USA) and 4G LC- plus AccuTOF (JEOL, Peabody, USA) | Positive ionization mode | (Maric and Harvey 2017) | |
DART Ion Source (Ionsense, USA) and JMS-4000LC AccuTOF (JEOL, JAPAN) | Both positive and negative ionization mode | (Moustafa and Bridge 2017) | |
DART-100 Ion Source (Ionsense, USA) and AccuTOF (JEOL) | Both positive and negative ionization mode | (Proni and Cohen 2017) | |
DART-SVP Ion Source (Ionsense, USA) and JMS-4000LC AccuTOF-LP 4G (JEOL, JAPAN) | Both positive and negative ionization mode | (Baumgarten and Marić 2018) | |
AccuTOF-DART (JEOL, USA) HRMS with resolving power of 6000 FWHM (full width at half maximum) | Positive ionization mode | (Coon and Beyramysoltan 2019) | |
DART-SVP Ion Source (Ionsense, USA) and JMS-4000LC AccuTOF-LP 4G (JEOL, JAPAN) | Positive ionization mode | (Bridge and Marić 2019) |