Table 3 The brain and plasma S100β in cannabis- and/or tramadol-treated rats

Normal control

139.7 ± 5.0

116.5 ± 5.2

Cannabis 5 mg/kg

109.4 ± 3.9^*

116.3 ± 6.7

Cannabis 10 mg/kg

107.9 ± 4.8^*

105.97 ± 4.9

Cannabis 20 mg/kg

113.03 ± 3.6^*

98.9 ± 3.3^*

Tramadol 5 mg/kg

132.2 ± 4.7

109.7 ± 4.4

Tramadol 10 mg/kg

153.55 ± 3.5^#

105.5 ± 6.5

Tramadol 20 mg/kg

162.5 ± 3.3^*#

97.85 ± 3.7^*

Tramadol 10 mg/kg + cannabis 5 mg/kg

102.52 ± 4.3^*+

103.23 ± 3.1

Tramadol 10 mg/kg + cannabis 10 mg/kg

114.07 ± 4.4^*+

102.2 ± 4.2

Tramadol 10 mg/kg + cannabis 20 mg/kg

101.87 ± 6.2^*+

91.23 ± 3.7^*