Table 1 Brain and plasma UCH-L1 in cannabis- and/or tramadol-treated rats

Normal control

1.30 ± 0.01

1.25 ± 0.08

Cannabis 5 mg/kg

1.60 ± 0.09^*

1.30 ± 0.12^#

Cannabis 10 mg/kg

1.60 ± 0.06^*

1.40 ± 0.11^#

Cannabis 20 mg/kg

1.65 ± 0.02^*

2.00 ± 0.12^*

Tramadol 5 mg/kg

1.70 ± 0.05^*

1.45 ± 0.05^#

Tramadol 10 mg/kg

1.85 ± 0.03^*

1.65 ± 0.07^*#

Tramadol 20 mg/kg

1.96 ± 0.03^*#

2.30 ± 0.10^*

Tramadol 10 mg/kg + cannabis 5 mg/kg

1.54 ± 0.08⁺

1.525 ± 0.06^+#

Tramadol 10 mg/kg + cannabis 10 mg/kg

1.55 ± 0.04^*+

1.60 ± 0.02^*+#

Tramadol 10 mg/kg + cannabis 20 mg/kg

1.65 ± 0.04^*+

1.65 ± 0.08^*+#