Fig. 5

Representative H&E stained sections from the striatum of rats treated with a saline; b cannabis 5 mg/kg showing cytoplasmic vacuolations (V) and pyknotic darkly stained nuclei (P); c cannabis 10 mg/kg showing cytoplasmic vacuolations (V), pyknotic nuclei (P), and apoptotic cells (A); d cannabis 20 mg/kg showing (left) cytoplasmic vacuolations (V), pyknotic nuclei (P), and apoptotic cells (A) and (right) hemorrhage (H) and focal gliosis (arrow); e tramadol 5 mg/kg showing cytoplasmic vacuolations (V) and pyknotic nuclei (P); f tramadol 10 mg/kg showing cytoplasmic vacuolations (V), pyknotic nuclei (P), and apoptotic cells (A); g tramadol 20 mg/kg showing (left) cytoplasmic vacuolations (V), pyknotic nuclei (P), apoptotic cells (A), and hemorrhage (H) and (right) and diffuse gliosis (arrow); h cannabis 5 mg/kg + tramadol 10 mg/kg showing, cytoplasmic vacuolations (V), pyknotic nuclei (P), and hemorrhage (H); i cannabis 10 mg/kg + tramadol 10 mg/kg showing cytoplasmic vacuolations (V), pyknotic nuclei (P), and apoptotic cells (A). Hemorrhage (H); j cannabis 20 mg/kg + tramadol 10 mg/kg showing (left) cytoplasmic vacuolations (V), pyknotic nuclei (P), and apoptotic cells (A) and (right) and gliosis (arrow) (H&E × 400)