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Table 3 Comparison between on immune-modulatory markers, inflammatory markers and AChE activity within the four studied groups

From: Therapeutic effects of N-acetylcysteine against malathion-induced hepatotoxicity

Measured parameters

Group 1

Group 2

Group 3

Group 4

leukocyte count (cells/mm3)

4.1 ± 0.38

4.12 ± 0.47

11.73 ± 2.6ab

6.81 ± 1.67abc

MPO (U/gm)

2.49 ± 0.38

2.79 ± 0.47

11.7 ± 5.97ab

5.32 ± 2.37abc

CD4 %

32.41 ± 2.52

32.26 ± 4.23

57.18 ± 9.86ab

44.1 ± 6.28abc

CD8 %

25.52 ± 2.98

28.16 ± 3.97

58.92 ± 11.69ab

35.03 ± 8.88abc

IL-1b

1 ± 0.03

1.01 ± 0.02

6.80 ± 2.26ab

2.95 ± 1abc

IL-6

1.17 ± 0.6

1.04 ± 0.05

5.72 ± 1.92ab

2.71 ± 1.0abc

IFN-γ

1.04 ± 0.06

1.04 ± 0.05

9.24 ± 2.82ab

3.48 ± 1.08abc

AChE (μ/mg protein)

23.9 ± 3.48

30.08 ± 5.37a

12.37 ± 3.69ab

21.91 ± 5bc

  1. Values are represented in mean ± standard deviation (S.D)
  2. Group 1: control (negative), group 2: NAC only, group 3: malathion only, group 4: malathion plus NAC
  3. aSsignificant compared to corresponding value in group 1 at P < 0.05
  4. bSignificant compared to corresponding value in group 2 at P < 0.05
  5. cSignificant compared to corresponding value in group 3 at P < 0.05