Therapeutic effects of N-acetylcysteine against malathion-induced hepatotoxicity

Egyptian Journal of Forensic Sciences

Table 2 Comparison between liver function enzymes, oxidant/antioxidant status markers and genotoxicity markers within the four studied groups

Measured parameters	Group 1	Group 2	Group 3	Group 4
ALT (U/l)	15.88 ± 2.83	15.88 ± 3.26	58.04 ± 17.74^ab	26.16 ± 6.61^abc
AST (U/l)	17.84 ± 2.37	17.32 ± 2.97	51.88 ± 11.17^ab	26.08 ± 6.42^abc
ALP (U/l)	126.68 ± 4.8	127.85 ± 7.02	288.78 ± 32.84^ab	164.97 ± 17.88^abc
LDH (U/l)	88.48 ± 7.94	80.2 ± 5.24	178.76 ± 32.22^ab	113.8 ± 12.53^abc
GSH (mmol/gm)	58.96 ± 3.99	59.94 ± 4.15	27.8 ± 8.38^ab	47.07 ± 8.36^abc
MDA (nmol/gm)	5.94 ± 1.89	5.94 ± 0.64	34.26 ± 11.31^ab	14.69 ± 5.39^abc
TAC (nmol/gm)	25.52 ± 3.09	29.78 ± 4.63^a	16.32 ± 4.97^ab	22.56 ± 5.47^bc
Apoptosis gene “Bax”	1.02 ± 0.02	1.02 ± 0.02	5.58 ± 1.64^ab	2.82 ± 0.81^abc
Antipoptosis gene “Bcl-2”	1.01 ± 0.02	1.01 ± 0.01	0.35 ± 0.17^ab	0.71 ± 0.19^abc
DNA fragmentation	1.92 ± 0.34	1.88 ± 0.36	33.75 ± 10.81^ab	3.66 ± 2.38^c

Values are represented in mean ± standard deviation (S.D)
Group 1: control (negative), group 2: NAC only, group 3: malathion only, group 4: malathion plus NAC
^aSignificant compared to corresponding value in group 1 at P < 0.05
^bSignificant compared to corresponding value in group 2 at P < 0.05
^cSignificant compared to corresponding value in group 3 at P < 0.05