Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin

Egyptian Journal of Forensic Sciences

Table 3 Changes in oxidative stress markers in the testis of mice after 4 weeks of exposure to curcumin (200 mg/kg/day), malathion (27 mg/kg bw), and their combination. n = 12 mice for each group

Parameters	G1 (control)	G2 (curcumin)	G3 (malathion)	G4 (malathion + curcumin)
CAT (U/g tissue)	347.50 ± 17.78	348.33 ± 19.28	216.33 ± 12.72^ab	318.00 ± 19.39^c
SOD (U/g tissue)	293.33 ± 6.02	298.83 ± 7.36	227.33 ± 11.09^ab	281.83 ± 9.70^c
GSH (mmol/gm tissue)	45.18 ± 3.42	47.56 ± 4.22	30.78 ± 2.62^ab	46.48 ± 2.38^c
GPx (mmol/gm tissue)	6.68 ± 0.32	6.78 ± 0.42	4.36 ± 0.24^ab	5.98 ± 0.28^c
MDA (mmol/g tissue)	41.67 ± 3.39	44.33 ± 3.08	86.66 ± 4.03^ab	49.66 ± 3.44^c

Data are mean ± SD
G1 control, G2 curcumin, G3 malathion, G4 malathion + curcumin, CAT catalase, SOD superoxide dismutase, GSH glutathione, GPx glutathione peroxidase, MDA malondialdehyde
^aCompared to the control (G1) group—significant at p < 0.05
^bCompared to curcumin (G2) group—significant at p < 0.05
^cCompared to malathion (G3) group—significant at p < 0.05