Malathion induced testicular toxicity and oxidative damage in male mice: the protective effect of curcumin

Egyptian Journal of Forensic Sciences

Table 1 Changes in body weight and testis weight of mice after 4 weeks of exposure to curcumin (200 mg/kg/day), malathion (27 mg/kg bw), and their combination. n = 12 mice for each group

Parameters	G1 (control)	G2 (curcumin)	G3 (malathion)	G4 (malathion + curcumin)
IBW (g)	25.66 ± 3.01	26.16 ± 2.56	27.83 ± 3.12	27.50 ± 3.01
FBW (g)	31.33 ± 1.36	31.83 ± 1.60	26.00 ± 1.67^ab	32.00 ± 1.67^c
RBW	122.99 ± 9.62	122.49 ± 11.37	94.02 ± 7.83^ab	117.33 ± 12.29^c
TW	0.26 ± 0.03	0.27 ± 0.03	0.18 ± .02^ab	0.27 ± .02^c
RTW	0.81 ± 0.06	0.84 ± 0.09	0.69 ± 0.05^ab	0.85 ± .06^c

Data are mean ± SD. Relative body weight = (final body weight/initial body weight) × 100. Relative testis weight = (testis weight/final body weight) × 100
G1 control, G2 curcumin, G3 malathion, G4 malathion + curcumin, IBW initial body weight, FBW final body weight, TW testis weight, RBW relative body weight, RTW relative testis weight
^aCompared to the control (G1) group—significant at p < 0.05
^bCompared to the curcumin (G2) group—significant at p < 0.05
^cCompared to the malathion (G3) group—significant at p < 0.05