Parameter | Control | 5 mg/kg bw | 50 mg/kg bw | 300 mg/kg bw | 2000 mg/kg bw |
---|---|---|---|---|---|
Male | |||||
RBC (× 106/mm3) | 6.26 ± 0.06 | 5.78 ± 0.06 NS | 7.36 ± 0.04 NS | 5.91 ± 0.01 NS | 6.74 ± 0.08 NS |
HGB (g/dL) | 11.29 ± 0.06 | 10.50 ± 0.05 NS | 12.26 ± 0.27 NS | 11.29 ± 0.09 NS | 14.16 ± 0.14 NS |
PCV (%) | 37.76 ± 0.06 | 38.76 ± 0.05 NS | 39.86 ± 0.24 NS | 38.26 ± 0.02 NS | 37.33 ± 0.03 NS |
MCV (fL) | 55.33 ± 0.23 | 54.30 ± 0.02 NS | 52.80 ± 0.52 NS | 55.63 ± 0.06 NS | 52.23 ± 0.03 NS |
MCH (pg) | 19.41 ± 0.01 | 18.03 ± 0.08 NS | 17.10 ± 0.15 NS | 19.50 ± 0.28 NS | 21.43 ± 0.03 NS |
MCHC (g/dL) | 34.77 ± 0.08 | 33.37 ± 0.27 NS | 32.26 ± 0.18 NS | 34.73 ± 0.22 NS | 34.86 ± 0.08 NS |
WBC (mm3) | 7.08 ± 0.03 | 7.66 ± 0.03 NS | 6.98 ± 0.06 NS | 7.56 ± 0.028 NS | 7.09 ± 0.05 NS |
LYM (%) | 76.37 ± 0.02 | 91.53 ± 0.79* | 92.13 ± 0.53* | 93.20 ± 0.20* | 92.60 ± 0.56* |
Female | |||||
RBC (× 106/mm3) | 4.71 ± 0.01 | 6.48 ± 0.01 NS | 8.34 ± 0.02 NS | 6.64 ± 0.02 NS | 6.17 ± 0.08 NS |
HGB (g/dL) | 12.56 ± 0.08 | 11.41 ± 0.01 NS | 12.83 ± 0.06 NS | 11.83 ± 0.03 NS | 12.00 ± 0.06 NS |
PCV (%) | 41.20 ± 0.005 | 38.13 ± 0.03 NS | 42.40 ± 0.26 NS | 39.80 ± 0.05 NS | 40.16 ± 0.17 NS |
MCV (fL) | 53.08 ± 0.01 | 53.18 ± 0.01 NS | 51.36 ± 0.03 NS | 54.36 ± 0.02 NS | 51.97 ± 0.03 NS |
MCH (pg) | 18.28 ± 0.04 | 17.41 ± 0.01 NS | 15.46 ± 0.02 NS | 18.00 ± 0.05 NS | 19.29 ± 0.09 NS |
MCHC (g/dL) | 35.66 ± 0.02 | 32.18 ± 0.01 NS | 30.23 ± 0.13 NS | 33.33 ± 0.03 NS | 35.22 ± 0.02 NS |
WBC (mm3) | 8.50 ± 0.15 | 5.88 ± 0.01 NS | 8.13 ± 0.03 NS | 7.18 ± 0.01 NS | 8.41 ± 0.01 NS |
LYM (%) | 65.06 ± 0.06 | 88.82 ± 0.03* | 92.13 ± 0.12* | 90.19 ± 0.09* | 91.40 ± 0.26* |