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Table 2 Serum biochemical values of the control and model groups

From: Single-dose acute toxicity of THJ-2201 designer Cannabis drug: LD50 and hematological and histological changes in mice

Parameter Control 5 mg/kg bw 50 mg/kg bw 300 mg/kg bw 2000 mg/kg bw
Male
 RBC (× 106/mm3) 6.26 ± 0.06 5.78 ± 0.06 NS 7.36 ± 0.04 NS 5.91 ± 0.01 NS 6.74 ± 0.08 NS
 HGB (g/dL) 11.29 ± 0.06 10.50 ± 0.05 NS 12.26 ± 0.27 NS 11.29 ± 0.09 NS 14.16 ± 0.14 NS
 PCV (%) 37.76 ± 0.06 38.76 ± 0.05 NS 39.86 ± 0.24 NS 38.26 ± 0.02 NS 37.33 ± 0.03 NS
 MCV (fL) 55.33 ± 0.23 54.30 ± 0.02 NS 52.80 ± 0.52 NS 55.63 ± 0.06 NS 52.23 ± 0.03 NS
 MCH (pg) 19.41 ± 0.01 18.03 ± 0.08 NS 17.10 ± 0.15 NS 19.50 ± 0.28 NS 21.43 ± 0.03 NS
 MCHC (g/dL) 34.77 ± 0.08 33.37 ± 0.27 NS 32.26 ± 0.18 NS 34.73 ± 0.22 NS 34.86 ± 0.08 NS
 WBC (mm3) 7.08 ± 0.03 7.66 ± 0.03 NS 6.98 ± 0.06 NS 7.56 ± 0.028 NS 7.09 ± 0.05 NS
 LYM (%) 76.37 ± 0.02 91.53 ± 0.79* 92.13 ± 0.53* 93.20 ± 0.20* 92.60 ± 0.56*
Female
 RBC (× 106/mm3) 4.71 ± 0.01 6.48 ± 0.01 NS 8.34 ± 0.02 NS 6.64 ± 0.02 NS 6.17 ± 0.08 NS
 HGB (g/dL) 12.56 ± 0.08 11.41 ± 0.01 NS 12.83 ± 0.06 NS 11.83 ± 0.03 NS 12.00 ± 0.06 NS
 PCV (%) 41.20 ± 0.005 38.13 ± 0.03 NS 42.40 ± 0.26 NS 39.80 ± 0.05 NS 40.16 ± 0.17 NS
 MCV (fL) 53.08 ± 0.01 53.18 ± 0.01 NS 51.36 ± 0.03 NS 54.36 ± 0.02 NS 51.97 ± 0.03 NS
 MCH (pg) 18.28 ± 0.04 17.41 ± 0.01 NS 15.46 ± 0.02 NS 18.00 ± 0.05 NS 19.29 ± 0.09 NS
 MCHC (g/dL) 35.66 ± 0.02 32.18 ± 0.01 NS 30.23 ± 0.13 NS 33.33 ± 0.03 NS 35.22 ± 0.02 NS
 WBC (mm3) 8.50 ± 0.15 5.88 ± 0.01 NS 8.13 ± 0.03 NS 7.18 ± 0.01 NS 8.41 ± 0.01 NS
 LYM (%) 65.06 ± 0.06 88.82 ± 0.03* 92.13 ± 0.12* 90.19 ± 0.09* 91.40 ± 0.26*
  1. Values represent the mean ± SE. NS not significant. SE significant error. *P < 0.05