|
Parameter
|
Control
|
5 mg/kg bw
|
50 mg/kg bw
|
300 mg/kg bw
|
2000 mg/kg bw
|
|---|
|
Male
|
|
RBC (× 106/mm3)
|
6.26 ± 0.06
|
5.78 ± 0.06 NS
|
7.36 ± 0.04 NS
|
5.91 ± 0.01 NS
|
6.74 ± 0.08 NS
|
|
HGB (g/dL)
|
11.29 ± 0.06
|
10.50 ± 0.05 NS
|
12.26 ± 0.27 NS
|
11.29 ± 0.09 NS
|
14.16 ± 0.14 NS
|
|
PCV (%)
|
37.76 ± 0.06
|
38.76 ± 0.05 NS
|
39.86 ± 0.24 NS
|
38.26 ± 0.02 NS
|
37.33 ± 0.03 NS
|
|
MCV (fL)
|
55.33 ± 0.23
|
54.30 ± 0.02 NS
|
52.80 ± 0.52 NS
|
55.63 ± 0.06 NS
|
52.23 ± 0.03 NS
|
|
MCH (pg)
|
19.41 ± 0.01
|
18.03 ± 0.08 NS
|
17.10 ± 0.15 NS
|
19.50 ± 0.28 NS
|
21.43 ± 0.03 NS
|
|
MCHC (g/dL)
|
34.77 ± 0.08
|
33.37 ± 0.27 NS
|
32.26 ± 0.18 NS
|
34.73 ± 0.22 NS
|
34.86 ± 0.08 NS
|
|
WBC (mm3)
|
7.08 ± 0.03
|
7.66 ± 0.03 NS
|
6.98 ± 0.06 NS
|
7.56 ± 0.028 NS
|
7.09 ± 0.05 NS
|
|
LYM (%)
|
76.37 ± 0.02
|
91.53 ± 0.79*
|
92.13 ± 0.53*
|
93.20 ± 0.20*
|
92.60 ± 0.56*
|
|
Female
|
|
RBC (× 106/mm3)
|
4.71 ± 0.01
|
6.48 ± 0.01 NS
|
8.34 ± 0.02 NS
|
6.64 ± 0.02 NS
|
6.17 ± 0.08 NS
|
|
HGB (g/dL)
|
12.56 ± 0.08
|
11.41 ± 0.01 NS
|
12.83 ± 0.06 NS
|
11.83 ± 0.03 NS
|
12.00 ± 0.06 NS
|
|
PCV (%)
|
41.20 ± 0.005
|
38.13 ± 0.03 NS
|
42.40 ± 0.26 NS
|
39.80 ± 0.05 NS
|
40.16 ± 0.17 NS
|
|
MCV (fL)
|
53.08 ± 0.01
|
53.18 ± 0.01 NS
|
51.36 ± 0.03 NS
|
54.36 ± 0.02 NS
|
51.97 ± 0.03 NS
|
|
MCH (pg)
|
18.28 ± 0.04
|
17.41 ± 0.01 NS
|
15.46 ± 0.02 NS
|
18.00 ± 0.05 NS
|
19.29 ± 0.09 NS
|
|
MCHC (g/dL)
|
35.66 ± 0.02
|
32.18 ± 0.01 NS
|
30.23 ± 0.13 NS
|
33.33 ± 0.03 NS
|
35.22 ± 0.02 NS
|
|
WBC (mm3)
|
8.50 ± 0.15
|
5.88 ± 0.01 NS
|
8.13 ± 0.03 NS
|
7.18 ± 0.01 NS
|
8.41 ± 0.01 NS
|
|
LYM (%)
|
65.06 ± 0.06
|
88.82 ± 0.03*
|
92.13 ± 0.12*
|
90.19 ± 0.09*
|
91.40 ± 0.26*
|
- Values represent the mean ± SE. NS not significant. SE significant error. *P < 0.05
