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Table 3 Comparison of testicular inflammatory (TNF-α, IL-6, IL-1β) and apoptotic (caspase-8 and caspase-3) parameters in all studied groups

From: The possible protective effect of the nuclear factor kappa B inhibitor pyrrolidine dithiocarbamate on tramadol-induced testicular damage in rats

Parameters

Groups (n = 10)

Group I

Group II

Group III

Group IV

TNFα (pg/mg protein)

mean ± SD

35.72 ± 3.48

32.72 ± 2.45

65.78 ± 7.6

43.11 ± 3.35

P value of LSD

 

P = 0.160a

P < 0.001*a,b

P < 0.01*a, P < 0.001*b,c

IL-6 (pg/mg protein)

mean ± SD

21.62 ± 2.16

20.46 ± 2.10

39.56 ± 5.45

27.1 ± 3.42

P value of LSD

 

P = 0.470a

P < 0.001*a,b

P < 0.01*a, P < 0.001*b,c

IL-1β (pg/mg protein)

mean ± SD

35.13 ± 3.13

34.02 ± 3.49

58.4 ± 4.74

42.3 ± 3.59

P value of LSD

 

P = 0.517a

P < 0.001*a,b

P < 0.001*a,b,c

Caspase-8 (nmol/min/ml)

mean ± SD

0.45 ± 0.07

0.41 ± 0.07

2.03 ± 0.44

1.07 ± 0.16

P value of LSD

 

P = 0.686a

P < 0.001*a,b

P < 0.001*a,b,c

Caspase-3 (μmol/min/ml)

mean ± SD

0.4 ± 0.05

0.37 ± 0.04

2.56 ± 0.38

1.19 ± 0.24

P value of LSD

 

P = 0.804a

P < 0.001*a,b

P < 0.001*a,b,c

  1. TNFα, tumor necrosis factor alpha; IL-6, interleukin 6; IL-1β, interleukin-1beta; SD, standard deviation; n, number of rats in each group; LSD, least significant difference
  2. *Significant result
  3. ap value versus group I
  4. bp value versus group II
  5. cp value versus group III